검색어를 입력하십시오. 검색양식 제출   Web DrHoon.net

Amended Bitter Orange - Ephedra in Disguise? So Why Do People Still Take It ?

If you read my last article about bitter orange, it was pretty clear how I felt about the herb. I'd read the available research concerning bitter orange, and while there was some evidence supporting bitter orange, the overall picture did not look good.

So that's the picture I painted, however, there were some facts that I was unaware of at the time, which I felt you might be interested in if you're researching bitter orange.

In order to lay these out, I want to answer four questions:

1. What Is Bitter Orange Really ?

2. So does Bitter Orange act similarly to ephedrine ?

3. What about the reports of adverse ill effects of bitter orange ?

4. Is bitter orange safe to use and does it work ?

It's a bit long, but what the heck !

What Is Bitter Orange Really ?:

The Bitter Orange extract found in popular fat burners, is made from the unripe fruit of the citrus aurantium tree. The fruit is picked when they are a dark green in color, halved, dried and then milled into a powder. This makes the herb Zhi Shi1. Bitter orange is the western name for Zhi Shi.

The bitter orange herb contains five alkaloids (see alkaloid definition5), the most dominant of which is Synephrine (the compound I referred to in my last article), structurally similar to ephedrine. However, while they are similar, they're not the same.

Both synephrine and ephedrine stimulate the sympathetic nervous system and at a cellular level, affect alpha cell receptors, and to a lesser extent, beta cell receptors6. Ephedrine will affect beta(1), beta(2) and beta(3) cell receptors, however, of the beta-cell receptors, synephrine appears to only affect beta(3) cells, those believed to be responsible for thermogenesis or fat burning affects7. Beta(1) and beta(2) receptors are believed to be responsible for cardiac and pulmonary functions.

So does Bitter Orange act similarly to ephedrine ?

Does it ? While previously, I've presented a very black and white view of whether it acts similarly to ephedrine, I am now not so sure.

There is some confusion as to how synephrine affects heart rates and blood pressure. Intravenously injected synephrine will cause increased heart rates and blood pressure, however, orally taken synephrine does not, and synephrine contained in most herbal weight loss supplements are taken orally.

Generally speaking because synephrine stimulates beta(3) cells but not beta(2) and beta(1) cells, it can provide the thermogenic effects without the undesirable cardiac side effects that ephedrine did.

What about the reports of adverse ill effects of bitter orange ?

The American Herbal Products Association has found that there were errors in the reported adverse event reports attributed to the use of bitter orange in September 20043. The association found that numbers reported in the media were in fact duplicates for adverse event reports for ephedrine, and when all was said and done, there was really only one report of an adverse reaction attributed to a bitter orange supplement, where no other ingredient was included in the supplement. In this particular case, it involved a 74 year old woman had been taking prescription medication and two other herbal preparations simultaneously. This one case occurred more than five years ago3.

What about the 55 year old woman reported by Nykamp DL, Fackih MN, Compton AL (2004), who experienced chest pain after consuming a supplement containing bitter orange. Researchers in this case study had commented "Based on the Naranjo probability scale, C. aurantium is possibly associated with this cardiovascular event"4, however, as bitter orange was not the only ingredient in the supplement, it cannot be known whether in this case, that bitter orange was the herb responsible.

Is bitter orange safe to use and does it work ?

Now there are many others, who felt as I did, that bitter orange is another Ephedra waiting to happen, and will have the same consequences. However, when bitter orange is taken in isolation, it does not have adverse side effects.

In fact, when it is combined with other selected herbs, it may have benefits for health and weight loss. Research performed with 20 individuals over six weeks found no adverse reactions occurred when citrus aurantium was combined with caffeine and St. Johns Wort2. They also found that the individuals who were given the supplement (group A) lost an average of 2.9% body fat. "In terms of actual fat loss, group A lost a significant amount (3.1 kg), whereas the control group demonstrated a tendency toward fat loss." So, this study has demonstrated that there are weight loss benefits involved here, but also the control group who received nothing exhibited a tendency towards fat loss, suggesting that if the study had been extended beyond 6 weeks, the control group would have lost body fat as well.

Conclusions:

2004 was not a great year for bitter orange in the media. It has successfully battled reports of adverse events alleged to be a result of consuming bitter orange. These numbers proved to be incorrect.

While synephrine the main alkaloid of bitter orange, is chemically similar to ephedrine, it is not the same as ephedrine and differs in the way it reacts pharmacologically within the human body.

Although at first look at the research, bitter orange presented with dangers that I wanted to warn against, a more in-depth look has revealed that bitter orange by itself is not dangerous. The citrus aurantium extract standardized for synephrine (3-6%) is accepted as safe7.

But hang on, before you click off this page, to go and find a fat burner with citrus aurantium in it, I do also want to say, that they can't be used as an alternative to good food and exercise.

Herbal supplements such as those containing bitter orange can be helpful but only when used within a weight loss strategy of balanced eating and exercise, and while they may benefit some, it may not benefit others and only your doctor will be able to make that decision for you6. The results may be slower, but a balanced diet and exercise are the keys to permanent and healthy weight loss. So while bitter orange may be helpful, you can obtain the same results without it. What-ever stage you are at with your health and fitness, diet and exercise are the two most important aspects.

If you do decide you'd like to try a supplement containing bitter orange, please consult your doctor before purchasing a bitter orange product.

Essentially if you consult your doctor about bitter orange, as we say in Australia - you can't go wrong, mate. Your doctor will be able to refer you to your nearest dietician and will recommend the best weight loss strategy for your situation.

References:

1. Jones, D., "Bitter Orange or Citrus Aurantium: same difference ?"

2. Colker et. al., (1999) Effects of Citrus Aurantium extract, caffeine, and St. John's Work on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr. Ther. Res. 60, 145 - 153.

3. American Herbal Products (2004) "FDA Spins Numbers on Bitter Orange AERs" Press Release

4. Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother. 2004 May;38(5):812-6. Epub 2004 Mar 16.

5. Definition of Alkaloids - any of hundreds of compounds found in plants with a nitrogen atom connected to two carbon atoms, and often formed in a ring structure. Many commonly known chemicals and drugs are alkaloids, including nicotine, cocaine, quinine, morphine, and ephedrine.

6. Dharmananda, S., SYNEPHRINE:Is Chih-shih (Zhishi) Toxic? Institute for Traditional Medicine, Portland, Oregon. See the schematic diagram for synephrine at the bottom of the page.

7. Supplement Watch on Synephrine

Other Sites of Interest:

Supplement Watch Newsletter

About The Author

Copyright © 2004 Jenny Mathers All Rights Reserved.

Research resource for fat burning foods and supplements. Fat burning food research information allowing you to take the guess work out of fat burning.

Yoga Videos

   

Critics say yoga at NY high school tries to spread Hinduism USA Today - 3 hours ago MASSENA, NY (AP) — A group of parents and religious leaders in upstate New York want yoga classes out of public schools, saying the instruction violates ...

What yoga can do for you Inquirer.net, Philippines - 5 hours ago And where there are millions of people whose lives have been transformed, or at the very least, improved by the practice of yoga, then you know that ...

200 hour Ashtanga Vinyasa Yoga Teacher Training with Caroline Klebl Mass Media Distribution LLC (press release), FL - 8 hours ago October 6, 2008 -- Caroline Klebl offers a comprehensive Yoga Teacher Training program to teachers, aspiring teachers and dedicated practitioners of yoga. ...

Yoga students seek balance, strength (VIDEO) GoErie.com, PA - 8 hours ago The desks are gone, replaced by yoga mats. Candles and covered lamps provide the lighting for a dozen women who work quietly through a series of stretches ...

Yoga more than just for meditation Abilene Reporter-News, TX - 13 minutes ago My doctor wants me to get more exercise, and she recommended yoga. I know yoga has become very popular in the past few years, but how will it help me? ...

Is It Safe to Use Online Yoga Courses? KTNV Las Vegas, NV - 2 hours ago Yoga is a growing trend, and it's getting more accessible than ever, but striking the perfect pose is easier said than done. Doctors have a warning for ...

Yoga plus one Belleville Intelligencer, Canada - 13 hours ago With one-year-old Willow on her lap, Kim Belanger-Mills demonstrates how to do yoga with a toddler in tow. Sometimes, her daughter sits on her abdomen as ...

Yoga "can help the memory-challenged" Totally Fitness Health and Fitness news, UK - 7 hours ago A yoga expert from the US is running a course in which those with memory problems, such as Alzheimer"s patients, can take part in the activity. ...

Program pushes yoga, meditation to inspire nonviolent attitudes The Spartan Daily, CA - 7 hours ago The YES+ program is based on yoga, meditation and breathing practices, according to the Web site, and will help students get rid of stress and learn ...

Bikram's Last Seminar: Words of Wisdom From a Yoga Guru Huffington Post, NY - 13 hours ago PHILADELPHIA -- Spending Saturday with the famous Bikram Choudhury, founder of Bikram's Yoga College of India, I was not expecting a quiet "ommmm" incense ...